Symposium

Stroke

Clinical Practice (assessment, diagnosis, treatment, knowledge translation/EBP, implementation science, program development)

The Biopsychosocial Storm of Post-Stroke Depression: From Neurobiology to Treatment (818599)

Presenter(s)

• 

  Abhishek Jaywant, PhD

  Assistant Professor of Neuropsychology
  Weill Cornell Medicine
  New York, New York

  Presentation Slides
• 

  Theodora Kanellopoulos, PhD

  Assistant Professor of Psychology
  Weill Cornell Medicine
  White Plains, New York
• 

  Michael W. O'Dell, MD

  Professor of Clinical Rehabilitation Medicine
  Weill Cornell Medicine
  New York, New York

Post-stroke depression (PSD) is associated with disruption to frontostriatal networks, including functional connectivity in regions relevant for cognitive control and emotion regulation. These neurobiological changes are accompanied by emotional and psychosocial stress that altogether contribute to the heterogeneous symptom presentation of PSD. Psychotherapies for PSD focus on helping patients regulate emotions, engage in activities, and reframe negative cognitions while also addressing the effects on the family, caregivers, and patient’s environment. Pharmacologic treatment can be effective in treating ongoing symptoms and in prophylaxis, but must be considered in the context of side-effects, impact on cognition, and impact on stroke functional recovery.

Learning Objectives:

• Identify changes in structural and functional brain network connectivity and how they interact with psychosocial changes to give rise to post-stroke depression.
• Describe behavioral interventions for post-stroke depression and their major therapeutic components.
• Describe the evidence for use of pharmacologic treatment for post-stroke depression, including side-effects and effects on stroke functional recovery.