Brain metastasis is associated with increased mortality in patients with cancer, 15-20% of patients will develop brain metastasis during the course of the disease. Characterizing clinically relevant brain metastasis models and exploring different options to deliver drugs across blood brain barrier in such models are fundamental for the development of novel therapies for metastatic brain tumors. We have created imageable breast to brain metastasis tumor models using patient derived brain seeking basal like breast cancer (BLBC) lines. We show a widespread distribution of micro- and macro-metastasis and the close association of tumor cells with blood vessels in the brain thus mimicking the multi-foci metastases observed in the clinics. These models enables us to investigate the pathophysiology of this little-known phenomenon and test the efficacy of new approach targeting the dormant cancer cells in perivascular niche. Next, we assessed the EGFR and DR4/5 levels in BLBC and show that brain seeking BLBC have higher EGFR and DR5 levels than their primary counterparts. We also show that intracarotid artery injection or intrathecal injection of stem cells engineered to express optical imaging markers home to metastatic brain tumors. These findings provide useful models for testing treatments for metastatic brain tumors and also provide insights into the changes in gene expression in metastatic BLBC and means to deliver therapeutics to metastatic tumors in the brain.