In this session, we will walk through different use cases of high-performance computing and quantum simulation in several areas of Life Sciences: structural biology, human, animal and plant genomics and drug development. We will briefly explain the challenges that our collaborative organizations (research centers, hospitals, pharma/biotech) are facing and how technologies have enabled them to achieve scientific excellence. We will outline the co-creation process that we have followed together to turn technologies in breakthroughs, generating tangible impact in society. The 1st case study will explain how the hybridization of AI and HPC technologies are the perfect blend to refine the structure of the SARS-Cov-2 spike protein reaching to a high-resolution 3D model that allows a better understanding of the mechanisms of infection. In the 2nd case in genomics, we will elaborate our one-decade collaboration in optimizing the HPC architecture for the second largest center in Europe in terms of sequencing capabilities. Furthermore, HPC usage will also be illustrated in terms of accelerating the implementation of precision medicine with an overview of our activities in the healthcare domain. Obviously, as a gaming-changing revolution of HPC, quantum simulation will be discussed as a powerful tool to improve the clinical trials processes.