Firefighters are often exposed to severe stressors, such as catastrophic injury to self or co-workers, gruesome victim incidents, rendering aid to seriously injured vulnerable victims, and death. In addition, firefighters are exposed to more common management-related stressors, such as work overload, staff shortages, poor communication, and lack of support. Because these incidents put a strain on emotional resources, firefighters must develop coping strategies. Existing research points to several different forms of coping that are more effective (e.g., exercise, social relationships) and less effective (e.g., drug/alcohol use and avoidance). Negative or ineffective coping strategies can lead to a variety of negative mental and physical health outcomes that increase the risk of firefighter death and injury, including depression, addiction, suicide, sickness, anxiety, anger, stress, heart conditions, and post-traumatic stress disorder. However, little is understood about the factors that influence firefighters’ coping strategies and willingness to seek help, such as fire culture, leadership, and home stressors, and how different strategies consequently influence affective and behavioral responses important for firefighter safety and well-being. Thus, using survey data from two U.S. fire departments, we intend to provide empirical insights on the conditions that predict when firefighters are more likely to engage in negative coping styles that lead to poor outcomes at the station-level. The findings from this study will assist fire service organizations in developing management practices and an overall culture that addresses workplace stressors, supports better mental and physical health outcomes for firefighters, and ensures success for the workforce and retention of employees.