Epilepsy and EEG fellow King Faisal Specialist Hospital and Research Centre Hamad town, Bahrain
Rationale: To examine the lateralizing value of unilateral peri-ictal and interictal headaches in patients with drug-resistant focal epilepsy (DRFE). Methods: Four-hundred consecutive patients undergoing pre-surgical evaluation for DRFE were interviewed. Patients with headache were broadly divided into two groups: peri-ictal and interictal headache. The lateralizing value of unilateral headache was compared in each group between three diagnoses: temporal lobe epilepsy (TLE), extratemporal lobe epilepsy (ETLE), and temporal-plus epilepsy (TEMP+ epilepsy). Results: Out of 400 patients, 169 (42.25%) had headaches. Peri-ictal headaches were experienced in 106 patients (26.5%) and interictal headaches were experienced in 63 (15.75%). In the peri-ictal group, unilateral headaches were present in 48 out of 60 patients (80%) with TLE; they were ipsilateral to the seizure focus in 45 out of 48 (93.75%). Unilateral headaches in patients with ETLE were present in 20 out of 31 patients (64.51%) and were ipsilateral to the seizure focus in 14 out of 20 (70%). In patients with TEMP+ epilepsy, unilateral peri-ictal headaches were present in nine out of 15 (60%); they were ipsilateral to the seizure focus in all nine patients (100%). In the interictal headache group, unilateral headaches were ipsilateral the seizure focus in nine out of 10 patients (90%) with TLE and five out of six patients (83.3%) with ETLE. None of the TEMP+ epilepsy patients had a unilateral interictal headache. Conclusions: Headache is a frequently encountered symptom in patients with drug resistant focal epilepsy (DRFE). When occurring in a unilateral fashion, it has a high lateralizing value in temporal and extratemporal lobe epilepsies. This has been demonstrated to be true for both peri-ictal and interictal headaches. In the vast majority of patients with DRFE, unilateral headache occurs ipsilateral to the seizure focus. Funding: Please list any funding that was received in support of this abstract.: No financial support was received to carry on this study. Click here to view image/table
