Track: 5. Neuro Imaging / 5B. Functional Imaging
Associate Research Specialist
University of Wisconsin-Madison
Higher FI frequency was correlated with increased short range connectivity in the right supramarginal gyrus, right postcentral gyrus, left caudate head, and left pars orbitalis. Further, direct comparison showed that these areas were more correlated with FI frequency than with FA frequency.
GTC frequency per se was not significantly correlated with brain connectivity changes (which may be due to low power given only few patients had GTC). Direct comparison to both FA and FI however showed higher average connectivity in the left anterior frontal cortex with more frequent GTC. Average connectivity in right frontal eye field and dorsolateral prefrontal cortex was also significantly more associated with GTC than with FI frequency.
Conclusions: Our findings suggest that even the least severe seizures (FA) may lead to increases in connectivity not only within but also outside of the limbic network in patients with TLE. FI seizures were associated with greater connectivity in the parietal and frontal lobes, while GTC frequency was specifically correlated with increased connectivity in the frontal lobe.
Funding: Please list any funding that was received in support of this abstract.: Epilepsy Connectome Project and Tiny Blue Dot Foundation