Track: 3. Neurophysiology / 3E. Brain Stimulation
National Autonomous University of Mexico, Distrito Federal, Mexico
A single administration of MPA induced Pgp overexpression in cortex (68 ± 13.4%, p< 0.05 vs the control group) and hippocampus (48.5 ± 14%, p< 0.05, vs the control group). This effect was avoided when TFS was applied prior to MPA. In animals with drug-resistant seizures, TFS alone did not modify the expression of the convulsive seizures. However, TFS combined with phenytoin reduced the seizure intensity, an effect associated with a lower prevalence of major seizures (50%, p=0.03 vs phenytoin alone). Our experiments demonstrated that TFS avoids the Pgp overexpression induced after a single convulsive seizure. In addition, TFS augments the phenytoin effects in an experimental model of drug-resistant seizures.
Conclusions: In conclusion, TFS avoids the Pgp overexpression induced by a single seizure and augments the effects of phenytoin in an experimental model of drug-resistant seizures. Therefore, TFS is potentially a new neuromodulatory strategy to revert the drug-resistant phenotype.
Funding: Please list any funding that was received in support of this abstract.: National Council of Science and Technology of Mexico (CONACYT) through Scholarship No. 622940 given to DPP