University of Arizona College of Medicine Phoenix, AZ
Jiali Ling, MS1, Saroja D. Geetha, MBBS1, Tyson Amundsen, MD2, Alec Zamarripa, MS3, Ricardo Badillo, MD4, Nirav Thosani, MD, MHA4, Bijun S. Kannadath, MBBS, MS1, Sushovan Guha, MD, PhD4, Michael B. Fallon, MD1; 1University of Arizona College of Medicine, Phoenix, AZ; 2Baylor Scott & White Health, Temple, TX; 3University of Arizona College of Medicine, Sacramento, CA; 4University of Texas Health Science Center, Houston, TX
Introduction: Clostridium difficile infection (CDI) is a nosocomial infection commonly observed following antibiotic therapy. Though male gender is considered a risk factor, not much is known about its effects on the outcomes of CDI. In this study we look at the trends of CDI incidence and mortality rate with respect to gender. Methods: Using the NIS database, all adult hospitalizations (age ≥ 18 years) between 2012 and 2017 were evaluated. Admissions with CDI were identified based on the appropriate ICD9 (00845) and ICD10 (A047, A0471, A0472) codes. The incidence and mortality rates with respect to gender were analyzed after applying recommended weights using Stata Statistical Software: Release 16. (STATACorp, College Station, TX) and pandas statistical package in Python. Results: In this study, 181,132,460 records were analyzed from 2012 -2017. A total of 2,089,130 admissions had CDI. Of those, 873,365 (41.8%) were males & 1,215,310 (58.2%) were females. The incidence of CDI continued to remain marginally high in males compared to females as the years progressed (from 1.16% to 1.07% (2012- 2017) in males vs 1.14% to 1.05% (2012-2017) in females). However this was not statistically significant. The mortality rates in males with CDI was 8.26 % in 2012 and decreased to 7.13% by 2017 (Table 1). In the same period, the mortality rates in females decreased from 6.67 % to 5.58%. Overall, males with CDI had a higher mortality rate than females (Figure 1). Discussion: There is an overall decrease in the incidence and mortality associated with CDI between 2012 and 2017 in the United States. However, the mortality rate was found to be higher in males compared to females during this time period. Though it is a statistically significant finding, further studies need to be done to evaluate the reasons for this disparity.
Table 1: CDI Incidence and mortality rates based on gender from 2012-2017: NIS database results
Figure 1: Mortality rates in patients with CDI based on gender from 2012-2017
Disclosures: Jiali Ling indicated no relevant financial relationships. Saroja Geetha indicated no relevant financial relationships. Tyson Amundsen indicated no relevant financial relationships. Alec Zamarripa indicated no relevant financial relationships. Ricardo Badillo indicated no relevant financial relationships. Nirav Thosani indicated no relevant financial relationships. Bijun Kannadath indicated no relevant financial relationships. Sushovan Guha indicated no relevant financial relationships. Michael Fallon indicated no relevant financial relationships.