John H. Stroger, Jr. Hospital of Cook County, LA
We queried the National Inpatient Sample (NIS) database from 2006-2014. We selected patients with a diagnosis of CDI using the appropriate ICD-9 codes. We identified patients with Cannabis use disorder and additional variables including long term use of ASA, steroids, antibiotics, and a diagnosis of inflammatory bowel disease. Categorical variables were compared using Chi-square Test. Predictors of in-hospital mortality and colectomy were evaluated by multivariate logistic regression.
A total of 938,870 weighted discharges with a diagnosis of CDI were analyzed from 2006 to 2014 from the NIS database. Mortality was 3% (27,900) and colectomy during hospitalization was 0.7% (6,848). 0.4% (3,518) had a diagnosis of a cannabis use disorder. Cannabis use was more prevalent in younger patients (mean age 42.01 years vs. non-users 69.09 years p< 0.001) and more likely to be male (56.7%). After multivariate logistic regression analysis, cannabis use resulted as a predictor of better outcomes in terms of colectomy (OR 0.539, p=0.037) and mortality during admission (OR 0.381, p=0.032).
Cannabis use is associated with lower odds of colectomy and inpatient mortality in patients admitted to the hospital with CDI. Further studies are required to establish potential therapeutic benefits of compounds within cannabis for CDI.
Table 1. Summary of demographic characteristics of all CDI discharges between 2006 and 2014
Table 2. Independent predictors of mortality in patients admitted for CDI: multivariate logistic regression analysis of patients in the Nationwide Inpatient Database in 2006-2014
Table 3. Independent predictors of bowel resection during admission in patients admitted for CDI: multivariate logistic regression analysis of patients in the Nationwide Inpatient Database in 2006-2014
Parth Desai indicated no relevant financial relationships.
Estefania Flores indicated no relevant financial relationships.
Chimezie Mbachi indicated no relevant financial relationships.
Alexander Nguyen indicated no relevant financial relationships.
Krishna Moturi indicated no relevant financial relationships.
Naser Yamani indicated no relevant financial relationships.