Maria Gonzalez, MD, Lucia Rivera-Matos, MD, Timothy McGorisk, MD; University of Illinois at Chicago, Chicago, IL
Introduction: Colorectal carcinoma (CRC) is the third most common cause of cancer-related death in the United States. University of Illinois Hospital serves a population predominately comprised of ethnic minorities. The aim of this study was to analyze if there are racial/ethnic disparities in the diagnosis of colon polyps to improve early detection and CRC prevention. Methods: After institutional review board approval, we performed a retrospective review of patients that underwent polypectomy on surveillance, screening, or diagnostic colonoscopies in our institution between March 2019 to January 2020. Information about race/ethnicity, age, sex, polyp type, localization, presence of advanced features or ≥3 pre-cancerous polyps were analyzed. Results: 401 patients were included in the study, and a total of 1166 polyps were included. Two hundred eleven patients (52.6%) were male and 190 (47.4%) were female. 53.4% were blacks/Non-Hispanic or Latino (B/NH-L) (n= 214), 17.5% were white (W/NH-L) (n= 70), 25.2% were Other/ Hispanic-Latino (O/HL) (n=101), and 4% were Asian (A/NH-L; n= 16). No significant gender effect was noted on the likelihood of different types of polyps (Fisher’s exact test p-value= 0.7204). Race/ethnicity had borderline significant effect on the likelihood of having advanced adenoma or ≥3 TAs (chi-squared test p-value=0.079). There were 5 (7.1%) W/NH-L, 12 (5.6%) B/NH-L, 3 (3%) O/HL, and 1 (6.2%) A/NH-L who had high grade dysplasia (HGD). However, there was no significant correlation between race/ethnicity and HGD (Fisher’s exact test p-value=0.5364). A statistical difference was noted when comparing race/ethnicity and probabilities of having different types of polyps (chi-squared test p-value =0.01269). Comparing sessile serrated lesion (SSL) incidence on B/NH-L vs other races/ethnicities, B/NH-L had higher likelihood of developing SSL (Fisher’s exact test p-value= 0.04438). Discussion: Our study demonstrated that race/ethnicity has an effect on the likelihood of having different polyp types, including SSLs, which were more prevalent in the B/NH-L population. This information can be used to guide future studies to better serve underrepresented minorities in Colorectal Cancer screening programs.
Table 1. Polyp type, localization, and presence of advanced adenoma and/or ≥3 polyps in different races/ethnicities. TA = tubular adenoma, TVA = tubulovillous adenoma, SSL = sessile serrated lesion, HP = hyperplastic polyp, AC = adenocarcinoma.
Disclosures: Maria Gonzalez indicated no relevant financial relationships. Lucia Rivera-Matos indicated no relevant financial relationships. Timothy McGorisk indicated no relevant financial relationships.