Achintya D. Singh, MD, MBBS, Scott Gabbard, MD; Cleveland Clinic Foundation, Cleveland, OH
Introduction: Neuromodulators such as buspirone and mirtazapine have been shown to be effective therapy for functional dyspepsia (FD). The aim of this study is to assess efficacy of buspirone and mirtazapine in patients with dyspepsia following surgical fundoplication.
Methods: This is a case series of three patients who were started on buspirone and/or mirtazapine for dyspeptic symptoms following surgical fundoplication. Discussion: Three female patients aged 74-84 years with history of surgical fundoplication were started on either buspirone and/or mirtazapine (Table). Time from surgery to presentation in the clinic for FD ranged between 3-10 years. Two of the patients noticed significant improvement in their FD after initiation of therapy and continued therapy. One patient could not tolerate buspirone due to its side effects of flushing, dizziness and nausea, and discontinued therapy. All side effects resolved shortly after discontinuation. These patients had reported significant loss of weight due to their ongoing dyspeptic symptoms. The patients who tolerated the therapy reported significant weight gain after initiation of the therapy. Buspirone and mirtazapine improved post-fundoplication dyspeptic symptoms in two of three patients. Further study regarding use of neuromodulators in this population is warranted.
Table: Features of the included patients.
Disclosures: Achintya Singh indicated no relevant financial relationships. Scott Gabbard indicated no relevant financial relationships.