Yun Yan, PhD1, Satish S. Rao, MD, PhD, FACG2, Xuelian Xiang, PhD1, Anam A. Herekar, MBBS1, Shashana Fiedler, MS1, Enoe Jimenez, MD3, Amol Sharma, MD, MS, FACG1; 1Augusta University, Augusta, GA; 2Medical College of Georgia at Augusta University, Augusta, GA; 3Medical College of Georgia, Augusta, GA
Introduction: Abnormal anorectal sensation is commonly associated with anorectal disorders. Endoflip® is a novel technology that can measure anal canal sensation and distensibility.
Aim: To determine anorectal sensory properties in healthy subjects using Endoflip and examine its reproducibility and validity. Methods: Healthy subjects completed two studies of anal Endoflip, two weeks apart. An EndoFLIP probe (3-mm diameter, 8-cm long, highly compliant bag with 16 impedance sensors) was placed in the anus with center of balloon located in mid anal canal. Stool sensations (1 = no, 2 =First, 3= Constant, 4 =Desire, 5= Urgency to defecate) and discomfort/pain sensation (Likert 0-4) were assessed at each distending volume 10, 20, 30, 40 and 50 ml. Ramp and intermittent balloon distensions were performed in random sequence and during rest and squeeze. Test re-test reliability were assessed using intra-class correlation coefficient (ICC). Results: Twelve healthy subjects (M/F=5/7, 28.2 ± 9.5 years) participated. Mean scores for stool-like sensation increased stepwise, with both ramp and intermittent distensions, during rest and squeeze (Table 1, 2). Mean scores for discomfort/pain increased slightly and were below 0.8 (Table 1). For ramp distention, stool sensation during test showed high reproducibility for 10, 30, and 50 ml (ICC >0.686, P< 0.03, Table 1), and during squeeze for all balloon distension volumes (Table 1). For intermittent distention, the stool sensation at rest and with 10 ml and 20 mL were significantly reproducible, as well as for all distensions during squeeze manuever, and these were also highly reproducible (ICC >0.681, P< 0.035, Table 2). Discomfort/pain during rest and squeeze for most balloon volumes high reproducibility (ICC >0.764, P< 0.013, Table 1 and 2). Discussion: Endoflip is a reliable, noninvasive and useful tool for assessing anorectal stool sensation and discomfort. Data from ramp and intermittent methods were similar. It is potentially useful for assessment of anorectal sensation in anorectal disorders.
Disclosures: Yun Yan indicated no relevant financial relationships. Satish Rao indicated no relevant financial relationships. Xuelian Xiang indicated no relevant financial relationships. Anam Herekar indicated no relevant financial relationships. Shashana Fiedler indicated no relevant financial relationships. Enoe Jimenez indicated no relevant financial relationships. Amol Sharma indicated no relevant financial relationships.