Joshua Nguyen, BS, Deepthi Rao, MD, MS; University of Missouri, Columbia, MO
Introduction: Granular Cell Tumor (GCT) is a rare, usually benign lesion derived from Schwann Cells that is most commonly found in the skin or soft tissue. This entity is exceedingly rare in the gallbladder, with less than 10 reported cases. Here, we report a rare case of granular cell tumor in the gallbladder discovered after cholecystectomy secondary to cholecystitis.
Methods: The patient is a 34-year-old female who presented to the hospital for evaluation of chronic cholecystitis. Her initial symptoms led to imaging which showed thickening of the gallbladder with possible stones, and required laparoscopic cholecystectomy. Grossly, the gallbladder was distended with pink-tan mucosa and cholesterolosis. The specimen was sectioned to reveal a tan-white submucosal lesion measuring 0.4 cm in greatest dimension. Histologically, the tumor showed a well-circumscribed mass within the submucosa. The tumor cells appeared round with granular eosinophilic cytoplasm and were absent of necrosis, mitoses, or significant cytological atypia. The tumor cells were immunoreactive for S-100 staining. Together, these features were consistent with a granular cell tumor. As of today, there were no further complications regarding this diagnosis for the patient. Discussion: Granular cell tumors in the gallbladder, although exceedingly rare, can be diagnosed incidentally after evaluation of biliary tract symptoms. Fortunately, granular cell tumors generally have a good prognosis following complete resection of the mass.
Granular cell tumor, H & E staining at 200x magnification
Granular cell tumor, S-100 staining at 100x magnification
Disclosures: Joshua Nguyen indicated no relevant financial relationships. Deepthi Rao indicated no relevant financial relationships.