Resident Creighton University Arizona Health Education Alliance Phoenix, Arizona
Ishani Shah, MD1, Mehak M. Laharwal, MBBS2, Harsh Mehta, MD3, Abhishek Bhurwal, MBBS, MD4, Keng-Yu Chuang, MD5, Kambiz Kadkhodayan, MD1; 1Creighton University Arizona Health Education Alliance, Phoenix, AZ; 2Saint Barnabas Medical Center, Livingston, NJ; 3Saint Barnabas Medical Center, West Orange, NJ; 4Robert Wood Johnson Medical School, Rutgers University, New Brunswick, NJ; 5Creighton University Arizona Health Education Alliance/Valleywise Health, Phoenix, AZ
Introduction: Patients with chronic pancreatitis (CP) have increased risk of developing pancreatic cancer (PCA). While several genetic variations have been identified as potential risk factors, there is limited literature regarding the influence of comorbid conditions on the risk of progression from CP to PCA. The aim of our study is to compare the influence of demographic characteristics and co-morbidities on the risk of progression from CP to PCA. Methods: All adults hospitalized with CP during the years 2015 to 2017 were identified using the Nationwide Inpatient Sample (NIS). These patients were divided into two groups: those with a co-diagnosis of PCA (study group) and those without a co-diagnosis of PCA (control group). We compared demographic characteristics and comorbidities between the two groups. Descriptive analyses were compared using t-test for continuous data and chi-square test for categorical data. Statistical significance was assigned at 0.05. Results: During the three-year study period, there were 514,934 hospitalizations for patients with CP. Of these, 5,690 (1.37%) patients had a co-diagnosis of PCA. As shown in table 1, patients with CP who had PCA were more likely to be older (64.70 years vs 52.70 years; p< 0.001), more commonly men (58.52% vs 55.73%; p< 0.001) and predominantly White (71.4% vs 64.68%; p=0.001). Presence of pancreatic cyst (90.42% vs 75.46%; p=0.003), biliary obstruction (20.56% vs 2.16%; p=0.001) and diabetes mellitus (40.95% vs 35.98%; p< 0.001) was more common among patients with pancreatic cancer. Interestingly, our study found the presence of hypertriglyceridemia (0.79% vs 4.02%; p=0.001), NASH/NAFLD (0.26% vs 0.47%, p=0.001) and cryptogenic cirrhosis (0.18% vs 0.36%; p=0.01) to be less prevalent in patients with CP and PCA (Table 2). Discussion: Our study identifies an increased prevalence of old age, male sex, white ethnicity, pancreatic cysts and diabetes mellitus in patients with CP and PCA, thus identifying potential independent risk factors. Counter-intuitively, and contrary to popular belief, the presence of hypertriglyceridemia, NASH/NAFLD and cryogenic cirrhosis, were found to have a lower prevalence in patients with CP and PCA. Larger population studies are required for more robust data.
Demographic characteristics among patients with chronic pancreatitis with and without pancreatic cancer
Risk factors among patients with chronic pancreatitis with and without pancreatic cancer
Disclosures: Ishani Shah indicated no relevant financial relationships. Mehak Laharwal indicated no relevant financial relationships. Harsh Mehta indicated no relevant financial relationships. Abhishek Bhurwal indicated no relevant financial relationships. Keng-Yu Chuang indicated no relevant financial relationships. Kambiz Kadkhodayan indicated no relevant financial relationships.