Introduction: Prior studies have shown that patients with Barrett's Esophagus (BE) are at twice the risk of prostate cancer. The relationship between urogenital cancers and BE/ Esophageal Adenocarcinoma (EAC) is unclear as to the etiology but presumed to be related to obesity or male sex hormones. This study aimed to determine the occurrence of urogenital cancer in patients with BE and the risk factors associated with them. Methods: In this cohort study, we identified patients between January 2000 and June 2019 at a tertiary care center with a diagnosis of BE, confirmed by endoscopy and histology review. Electronic medical records were utilized by two providers independently to collect data on demographics, comorbidities, medications, endoscopic and histologic findings, cancer diagnosis and dates. For comparison, the control group included BE patients without cancer and the case group included BE patients with urogenital cancers. Multivariate analysis was performed to assess the risk factors associated with the occurrence of urogenital cancers. Results: During the study period, 204 patients had urogenital cancers and 1,377 did not develop any cancer. The different types of urogenital cancers included prostate cancer (n=128; 13.6%), renal (n=28; 3.0%), urinary bladder (n=25; 2.7%), uterine (n=9; 0.96%), testicular (n=6; 0.64%), ovarian (n=3; 0.32%), penile (n=2; 0.21%), urethral (n=2; 0.21%) and vulvar (n=1; 0.11%). The mean age of patients with urogenital cancers was 68 years, 87% were males and 96% caucasian. The differences between BE patients without cancer and those with urogenital cancer are presented in table 1. On multivariate analysis (table 2), odds of developing urogenital cancers were higher if they were males, had hyperlipidemia, diabetes mellitus and history of alcohol use and H2 receptor blocker medications. Body mass index highly correlated with other variables and was not used in the multivariable analysis. There was a trend towards significance by a 30% risk reduction with statin use. Discussion: In patients with BE, prostate cancer was the most common urogenital cancer. Men with metabolic syndrome in BE population were at increased risk of developing urogenital cancers. BE patients with these risk factors need to be counseled about prostate cancer screening. Furthermore, statin use and alcohol cessation are modifiable risk factors and should be reinforced.
Disclosures: Vedha Sanghi indicated no relevant financial relationships. Mythri Anil Kumar indicated no relevant financial relationships. Motasem Alkhayyat indicated no relevant financial relationships. Prabhat Kumar indicated no relevant financial relationships. Madhusudhan Sanaka indicated no relevant financial relationships. Prashanthi Thota indicated no relevant financial relationships.