Yi Jiang, MD1, Salil Chowdhury, BSc1, Binghong Xu, MD2, Umair M. Nasir, DO1, Sushil Ahlawat, MD1; 1Rutgers New Jersey Medical School, Newark, NJ; 2New Jersey Digestive Disease Associates, Metuchen, NJ
Introduction: Cholangitis is a serious clinical syndrome of the hepatobiliary system, which can progress to sepsis, multiorgan failure and death. It can result from various etiologies such as primary autoimmune processes and secondary biliary obstruction (gallstones, benign and malignant stenosis). The aim of this study was to determine trends in patients hospitalized with benign cholangitis and factors associated with its inpatient outcomes. Methods: The NIS database was used to identify hospitalized adult patients with cholangitis from 2010 to 2017 using ICD codes. Patients with malignancy of the gallbladder, bile duct, ampulla, duodenum or pancreas were excluded. Primary outcomes included the trend of prevalence, interventions, and inpatient outcomes. Secondary outcomes were factors that were independently associated with inpatient outcomes. Results: Between 2010 and 2017, there was an uptrend of total benign cholangitis hospitalizations (33.3 to 38.1 per 10,000 US adults, p< 0.0001) with an annual prevalence change of 0.972 (p< 0.0001). An uptrend in benign calculous cholangitis was also observed (p< 0.0001). For biliary intervention, there were downtrends in ERCP, percutaneous and open biliary procedures (p< 0.0001). Outcomes in this study also showed downtrends in mortality (p=0.0002) and length of stay (LOS) (p< 0.0001) with an uptrend in total hospital charges (p< 0.0001). After adjusting for covariates, the mortality was significantly higher among African American patients, >40 years old (especially >70), with Medicaid insurance, high Elixhauser comorbidity index (ECI) and specific comorbid conditions such as acute pancreatitis, HCV infection, bile duct obstruction and septicemia compared to the reference group. Total hospital charges were higher, and LOS was longer among patients with non-Caucasian ethnicities, high ECI and comorbid conditions such as cholecystitis, acute pancreatitis, HIV infection, bile duct obstruction and septicemia. Discussion: Between 2010 and 2017, there was an uptrend of benign cholangitis hospitalizations with an increased proportion of calculous cholangitis and a downtrend in biliary procedures. Overall mortality rates and LOS decreased, while the costs of hospitalization increased during this study period. Further analysis identified ethnic disparities in mortality. High ECI, comorbid pancreatic/biliary conditions, infection and septicemia were independently associated with worse outcomes.
Disclosures: Yi Jiang indicated no relevant financial relationships. Salil Chowdhury indicated no relevant financial relationships. Binghong Xu indicated no relevant financial relationships. Umair Nasir indicated no relevant financial relationships. Sushil Ahlawat indicated no relevant financial relationships.