Bioanalytics – Biomolecular
End-to-End Hot Topic
This presentation will focus on challenges and solutions when providing bioanalytical support for CD3 targeting bi-specific therapeutic antibodies, specifically focusing on assessment of therapeutic PK and immunogenicity potential. Author will discuss the assay platforms applicable for drug quantitation (PK), detection of anti-drug antibodies including MOA based assay design for cell based neutralizing antibody assay, mitigation procedures needed. In addition author will also present case studies of bioanalytical method development for several CD3 targeting bi-specific therapeutic modalities.