Clinical Pharmacology – Biomolecular
Biotherapeutics have come a long way since the initial introduction of replacement proteins. These therapeutics have also changed significantly over time and we have applied more and more advanced tools in Clinical Pharmacology as we have provided physicians the right information to treat patients effectively. This keynote presentation will highlight the application of numerous Quantitative Pharmacology approaches such as classical TMDD modeling, disease modeling, quantitative systems pharmacology (QSP), physiologically-based pharmacokinetics (PBPK) and pharmacometrics to enable rational decision-making such as drug-target identification, dose and schedule selection, drug interaction strategy, and input to study design during the development of biologics. With the advancement of novel technologies to generate and deliver biotherapeutics as well as the availability of advanced analytics and novel methodologies to analyze data, Clinical Pharmacology approaches will continue to evolve to inform real-time decisions for personalized treatment at the point of care.