Microneedles (MN) are microprojections used in dermatology to increase the absorption of topical formulations in a painless and minimally invasive way (Gill et al., 2008). Recent studies have also highlighted their usefulness for drug and vaccine delivery in the oral cavity in animal models (Ma et al., 2014). However, pain and discomfort associated with the application of microneedles in the oral cavity has not been evaluated. The objective of this study was to evaluate safety, pain and discomfort associated with the topical application of microneedles in different sites of the oral cavity as a new drug delivery strategy.
Nadia Cristina Fávaro Moreira– Dental School of Piracicaba
Henrique Ballassini Abdalla– Dental School of Piracicaba
Gabriela Gama Xavier Augusto– Dental School of Piracicaba
Maria Cristina Volpato– Dental School of Piracicaba
Harvinder Singh Gill– Texas Tech University
Michelle Franz Montan Braga Leite– Dental School of Piracicaba