Purpose: Mucoadhesive drug delivery systems are unique novel drug delivery systems because of the benefits derived from them as opposed to conventional oral dosage forms. Benefits include prolonged retention at the site of application, absence of first-pass metabolism, instant drug release, controlled drug release rate, reduction of dose frequency, and improved therapeutic outcome.The study aims at formulating biodegradable mucoadhesive buccal films containing metronidazole using Hydroxypropyl Methyl-Cellulose (HPMC) K15M, Eudragit® RL100, Carbopol® 940 as carriers and Propylene glycol, as plasticizer.
Methods: Metronidazole buccal mucoadhesive films was prepared by solvent casting technique using HPMC- K15M Eudragit®RL-100 and Carbopol® 940 with propylene glycol as plasticizer. The buccal films were evaluated for various physiochemical parameters, bioadhesion properties, in-vitro release parameters and drug-polymer compatibility studies using Fourier Transform Infrared (FT-IR) Spectroscopy, Differential Scanning Calorimetry (DSC). Morphological study was carried out using Scanning Electron Microscopy (SEM).
Results: The metronidazole mucoadhesive films showed uniformity in weight (0.24-0.35g) and thickness(0.12-0.22mm) with a high folding endurance. Moisture content was in the range of 3.13-5.10%. Swelling index ranged between 70.37 to 104.86%. Surface pH was between 5.95 to 6.85.The in vitro drug release profile of the buccal films ranged from 54.87 to 98.66% over 6hrs. FT-IR and DSC studies revealed that there was no incompatibility between the drug and the excipients used. SEM indicated that the films had smooth surfaces and there was a uniform distribution of the drugs.
Conclusion: Mucoadhesive buccal films containing metronidazole with a prolonged retention time, controlled release characteristics as well enhanced bioavailability have been formulated. This drug delivery system is likely to overcome the present draw-backs of conventional oral formulations of metronidazole useful for treating periodontal infections.
Oluwatobiloba Shoyombo
– University of LagosPrecious Bosah
– University of LagosKehinde Salako
– University of LagosOmotunde Okubanjo
– Dr, University of Lagos, LagosOmotunde Okubanjo
– Dr, University of Lagos, LagosOmotunde Okubanjo
– Dr, University of Lagos, Lagos246 Views